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Page 1
Oxidative stress and altered expression of peroxiredoxin genes family (PRDXS) and sulfiredoxin-1 (SRXN1) in human lung tissue following exposure to sulfur mustard.
Tahmasbpour Marzony E, Ghanei M, Panahi Y. Tahmasbpour Marzony E, et al. Exp Lung Res. 2016 May;42(4):217-26. doi: 10.1080/01902148.2016.1194501. Epub 2016 Jun 8. Exp Lung Res. 2016. PMID: 27266564
RESULTS: Mean of MDA and PC values in BAL fluid of patients (0.6467 0.05922 nmol/l and 1.391 0.421 nmol/mg, respectively) was higher than in controls (0.486 0.04615 nmol/l and 0.949 0.149 nmol/mg, respectively). Expression of all examined genes was in the order PRDX1> P …
RESULTS: Mean of MDA and PC values in BAL fluid of patients (0.6467 0.05922 nmol/l and 1.391 0.421 nmol/mg, respectively) was higher than in …
Neuroprotective effects of sulfiredoxin-1 during cerebral ischemia/reperfusion oxidative stress injury in rats.
Wu J, Chen Y, Yu S, Li L, Zhao X, Li Q, Zhao J, Zhao Y. Wu J, et al. Brain Res Bull. 2017 Jun;132:99-108. doi: 10.1016/j.brainresbull.2017.05.012. Epub 2017 May 24. Brain Res Bull. 2017. PMID: 28552673
Moreover, immunoblot analysis assessed the relationship between Srxn1 levels and Prdx1-4 as well as Prdx-SO3 activity both in vitro and in vivo models. We found that decreased Srxn1 reduced Prdx1-4 and enhanced Prdx-SO3 protein levels. In addition, kno …
Moreover, immunoblot analysis assessed the relationship between Srxn1 levels and Prdx1-4 as well as Prdx-SO3 activity both in …
Dysregulation of Redox Status in Urinary Bladder Cancer Patients.
Reszka E, Lesicka M, Wieczorek E, Jabłońska E, Janasik B, Stępnik M, Konecki T, Jabłonowski Z. Reszka E, et al. Cancers (Basel). 2020 May 21;12(5):1296. doi: 10.3390/cancers12051296. Cancers (Basel). 2020. PMID: 32455559 Free PMC article.
After Bonferroni correction, an association was found with KEAP1, OGG1, SEPW1 and DNMT1. Early recurrence was associated with the down-regulation of PRDX1 and SRXN1 at the time of diagnosis. Peripheral redox status is significantly dysregulated in the blood of UBC p …
After Bonferroni correction, an association was found with KEAP1, OGG1, SEPW1 and DNMT1. Early recurrence was associated with the down-regul …
DDAH1 recruits peroxiredoxin 1 and sulfiredoxin 1 to preserve its activity and regulate intracellular redox homeostasis.
Yuan J, Yu Z, Zhang P, Luo K, Xu Y, Lan T, Zhang M, Chen Y, Lu Z. Yuan J, et al. Redox Biol. 2024 Apr;70:103080. doi: 10.1016/j.redox.2024.103080. Epub 2024 Feb 8. Redox Biol. 2024. PMID: 38354630 Free PMC article.
In the present study, DDAH1 was shown to interact with peroxiredoxin 1 (PRDX1) and sulfiredoxin 1 (SRXN1), and these interactions could be enhanced by oxidative stress. In HepG2 cells, H(2)O(2)-induced downregulation of DDAH1 and accumulation of ADMA were attenuated …
In the present study, DDAH1 was shown to interact with peroxiredoxin 1 (PRDX1) and sulfiredoxin 1 (SRXN1), and these interacti …
Peroxiredoxin 1 and its role in cell signaling.
Neumann CA, Cao J, Manevich Y. Neumann CA, et al. Cell Cycle. 2009 Dec 15;8(24):4072-8. doi: 10.4161/cc.8.24.10242. Epub 2009 Dec 5. Cell Cycle. 2009. PMID: 19923889 Free PMC article. Review.
Prdxs can be divided into three major subclasses: typical 2-cysteine (2-Cys) Prdxs (Prdx1-4), atypical 2-Cys Prdx (Prdx 5) and 1-Cys Prdx (Prdx 6). Recent evidence suggests that 2-Cys peroxiredoxins are more than "just simple peroxidases". ...However, further oxidation to …
Prdxs can be divided into three major subclasses: typical 2-cysteine (2-Cys) Prdxs (Prdx1-4), atypical 2-Cys Prdx (Prdx 5) and 1-Cys …
Identification of ferroptosis-related genes for overall survival prediction in hepatocellular carcinoma.
Luo L, Yao X, Xiang J, Huang F, Luo H. Luo L, et al. Sci Rep. 2022 Jun 15;12(1):10007. doi: 10.1038/s41598-022-14554-7. Sci Rep. 2022. PMID: 35705729 Free PMC article.
Then a prognostic model was established with four genes (GPX2, MT3, PRDX1, and SRXN1). PRDX1 is the hub gene of the prognosis model and has a high expression in hepatocellular carcinoma tumor tissue and cell lines. ...It also revealed the potential function o …
Then a prognostic model was established with four genes (GPX2, MT3, PRDX1, and SRXN1). PRDX1 is the hub gene of the pro …
Sulfiredoxin-1 enhances cardiac progenitor cell survival against oxidative stress via the upregulation of the ERK/NRF2 signal pathway.
Li X, He P, Wang XL, Zhang S, Devejian N, Bennett E, Cai C. Li X, et al. Free Radic Biol Med. 2018 Aug 1;123:8-19. doi: 10.1016/j.freeradbiomed.2018.05.060. Epub 2018 May 14. Free Radic Biol Med. 2018. PMID: 29772252 Free PMC article.
Meanwhile, overexpressing SRXN1 decreased the ROS generation and mitochondrial membrane potential, concomitant with the up-regulated primary antioxidant systems, such as PRDX1, PRDX3, TXNRD1, Catalase and SOD2. ...Interestingly, SRXN1 activated the ERK/NRF2 c …
Meanwhile, overexpressing SRXN1 decreased the ROS generation and mitochondrial membrane potential, concomitant with the up-regulated …
Chemical proteomics reveals new targets of cysteine sulfinic acid reductase.
Akter S, Fu L, Jung Y, Conte ML, Lawson JR, Lowther WT, Sun R, Liu K, Yang J, Carroll KS. Akter S, et al. Nat Chem Biol. 2018 Nov;14(11):995-1004. doi: 10.1038/s41589-018-0116-2. Epub 2018 Sep 3. Nat Chem Biol. 2018. PMID: 30177848 Free PMC article.
We also identified >55 heretofore-unknown protein substrates of the cysteine sulfinic acid reductase sulfiredoxin, extending its function well beyond those of 2-cysteine peroxiredoxins (2-Cys PRDX1-4) and offering new insights into the role of this unique oxidoreductase …
We also identified >55 heretofore-unknown protein substrates of the cysteine sulfinic acid reductase sulfiredoxin, extending its function …
18 results